The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621]

Entrez Summary

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5 '-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Ensembl ID:

ENSG00000135100

External Link:

CisBP

Interpro

IPR001356; IPR006897; IPR006898; IPR006899; IPR009057; IPR010982; IPR023219; ;

Protein Domain:

ENSP00000257555

Protein Domain:

ENSP00000443112

Protein Domain:

ENSP00000438804

Protein Domain:

ENSP00000481967

Protein Domain:

ENSP00000476181

Domain:

Protein: ENSP00000257555	DBD: Homeodomain	Other: HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin
Protein: ENSP00000443112	DBD: Homeodomain	Other: HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin
Protein: ENSP00000438804	DBD: Homeodomain	Other: HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin
Protein: ENSP00000481967	DBD: Homeodomain	Other: HNF-1_N, Telethonin
Protein: ENSP00000476181	DBD: Homeodomain	Other: HNF-1B_C, HNF-1_N, Telethonin

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8373770 16603721 9047360
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a ISS - GO_REF:0000024 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11980910
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
SELEX	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	Badis09		Inferred - Hnf1a (98% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hnf1a (98% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hnf1b (92% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - HNF1B (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HNF1B (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HNF1B (92% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HNF1B (92% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HNF1B (92% AA Identity, Homo sapiens)

Structure

Structure	PDB	1IC8

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for HNF1A (Homeodomain)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution