The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	ETS proto-oncogene 1, transcription factor [Source:HGNC Symbol;Acc:HGNC:3488]
Entrez Summary	TBA
Ensembl ID:	ENSG00000134954
External Link:	T077991_1.02
Interpro	IPR000418; IPR003118; IPR013761; IPR016311;
Protein Domain:
Protein: ENSP00000324578	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000376436	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000435666	DBD: ETS	Other: SAM_PNT
Protein: ENSP00000441430	DBD: ETS	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding non-sequence-specific_DNA Binding Transactivation_ PMIDS:12119294
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:21711453 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:11909962, PMID:15247905
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
ChIP-seq	ENCODE		Direct
ChIP-seq	ENCODE		Direct
SELEX	Hallikas2006		Direct
SELEX	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct
PBM	Wei10		Inferred - Ets1 (100% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETS1B_CHICK (100% AA Identity, Gallus gallus)
HT-SELEX	Nitta2015		Inferred - pnt (95% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - ETS2 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETS2 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS2 (90% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETS2 (90% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETS2 (90% AA Identity, Homo sapiens)
SMiLE-seq	Isakova2017		Inferred - GABPA (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - GABPA (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - GABPA (68% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Gabpa (68% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Gabpa (68% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Gabpa (68% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - GABPA (68% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - GABPA (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (65% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv1 (65% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Etv1 (65% AA Identity, Mus musculus)
Misc	HOMER		Inferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEX	Nitta2015		Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
PBM	Zoo_01		Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Ets65A (64% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (64% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv5 (64% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - FEV (64% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FEV (64% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - ERG (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (64% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ERG (64% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ERG (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETV5 (64% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - FEV (64% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (63% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (63% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk1 (63% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Erg (63% AA Identity, Mus musculus)
HT-SELEX	Nitta2015		Inferred - Ets96B (63% AA Identity, Drosophila melanogaster)
SMiLE-seq	Isakova2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (63% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Fli1 (63% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ELK1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (63% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (63% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (63% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK1 (63% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ELK1 (63% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - FLI1 (63% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Fli1 (63% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - elk4 (62% AA Identity, Tetraodon nigroviridis)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (62% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv4 (62% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETV4 (62% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV4 (62% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV2 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV2 (60% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV2 (60% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK3 (59% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk3 (59% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ELK3 (59% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK4 (58% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk4 (58% AA Identity, Mus musculus)
PBM	Wei10		Inferred - XP_911724.4 (58% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - ELK4 (58% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK4 (58% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK4 (58% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (56% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv3 (56% AA Identity, Mus musculus)

Structure

Structure	PDB	1K78

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 415, "endStyle": "curved", "aliStart": 336, "text": "Ets", "colour": "#009900", "aliEnd": 415, "start": 336, "href": "http://pfam.xfam.org/family/PF00178.20", "type": "pfama", "display": "true", "metadata": {"end": 415, "description": "The ETS domain is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. ", "database": "PfamA", "aliStart": 336, "scoreName": "E-value", "accession": "PF00178.20", "start": 336, "score": 3.3000000000000002e-37, "identifier": "Ets-domain", "type": "DBD", "aliEnd": 415}}, {"startStyle": "straight", "end": 136, "endStyle": "straight", "aliStart": 54, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 135, "start": 53, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 136, "description": NaN, "database": "PfamA", "aliStart": 54, "scoreName": "E-value", "accession": "PF02198.14", "start": 53, "score": 2.5e-34, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 135}}], "length": 442}

{"regions": [{"startStyle": "curved", "end": 459, "endStyle": "curved", "aliStart": 380, "text": "Ets", "colour": "#009900", "aliEnd": 459, "start": 380, "href": "http://pfam.xfam.org/family/PF00178.20", "type": "pfama", "display": "true", "metadata": {"end": 459, "description": "The ETS domain is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. ", "database": "PfamA", "aliStart": 380, "scoreName": "E-value", "accession": "PF00178.20", "start": 380, "score": 3.9e-37, "identifier": "Ets-domain", "type": "DBD", "aliEnd": 459}}, {"startStyle": "straight", "end": 180, "endStyle": "straight", "aliStart": 98, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 179, "start": 97, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 180, "description": NaN, "database": "PfamA", "aliStart": 98, "scoreName": "E-value", "accession": "PF02198.14", "start": 97, "score": 2.8999999999999998e-34, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 179}}], "length": 486}

TF Info Page for ETS1 (Ets)