TF Info Page for ETS1 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ETS proto-oncogene 1, transcription factor [Source:HGNC Symbol;Acc:HGNC:3488]
Entrez Summary This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Ensembl ID: ENSG00000134954
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; IPR016311;
Protein Domain: ENSP00000324578
Protein Domain: ENSP00000376436
Protein Domain: ENSP00000435666
Protein Domain: ENSP00000441430
Domain:
Protein: ENSP00000324578DBD: ETSOther: SAM_PNT
Protein: ENSP00000376436DBD: ETSOther: SAM_PNT
Protein: ENSP00000435666DBD: ETSOther: SAM_PNT
Protein: ENSP00000441430DBD: ETSOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
non-sequence-specific_DNA Binding
Transactivation_
PMIDS:12119294
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0000982
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:21711453
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:11909962, PMID:15247905
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
SELEXHallikas2006Direct
SELEXJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMWei10Inferred - Ets1 (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (100% AA Identity, Gallus gallus)
HT-SELEXNitta2015Inferred - pnt (95% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ETS2 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETS2 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETS2 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETS2 (90% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETS2 (90% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - GABPA (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GABPA (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GABPA (68% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gabpa (68% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (68% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (68% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gabpa (68% AA Identity, Mus musculus)
MiscHocoMocoInferred - GABPA (68% AA Identity, Homo sapiens)
MiscHOMERInferred - GABPA (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (65% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV1 (65% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv1 (65% AA Identity, Mus musculus)
PBMWei10Inferred - Etv1 (65% AA Identity, Mus musculus)
MiscHOMERInferred - ETV1 (65% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (64% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Ets21C (64% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Ets65A (64% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (64% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv5 (64% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - FEV (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FEV (64% AA Identity, Homo sapiens)
SELEXJASPARInferred - ERG (64% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (64% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (64% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ERG (64% AA Identity, Homo sapiens)
MiscHOMERInferred - ERG (64% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV5 (64% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FEV (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (63% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (63% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk1 (63% AA Identity, Mus musculus)
PBMWei10Inferred - Erg (63% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets96B (63% AA Identity, Drosophila melanogaster)
SMiLE-seqIsakova2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (63% AA Identity, Homo sapiens)
PBMWei10Inferred - Fli1 (63% AA Identity, Mus musculus)
SELEXJASPARInferred - ELK1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (63% AA Identity, Homo sapiens)
SELEXJASPARInferred - FLI1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (63% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (63% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK1 (63% AA Identity, Homo sapiens)
MiscHOMERInferred - ELK1 (63% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FLI1 (63% AA Identity, Homo sapiens)
MiscHOMERInferred - Fli1 (63% AA Identity, Mus musculus)
PBMZoo_01Inferred - elk4 (62% AA Identity, Tetraodon nigroviridis)
HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (62% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv4 (62% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETV4 (62% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (62% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV4 (62% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV2 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV2 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV2 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (59% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk3 (59% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ELK3 (59% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK3 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK4 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK4 (58% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk4 (58% AA Identity, Mus musculus)
PBMWei10Inferred - XP_911724.4 (58% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - ELK4 (58% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - ELK4 (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (58% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK4 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV3 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV3 (56% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv3 (56% AA Identity, Mus musculus)

Structure

Structure PDB 1K78

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution