The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	3 Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook

Description

Description:	methyl-CpG binding domain protein 2 [Source:HGNC Symbol;Acc:HGNC:6917]
Entrez Summary	TBA
Ensembl ID:	ENSG00000134046
External Link:
Interpro	IPR001739; IPR016177; IPR025884; ;
Protein Domain:
Protein: ENSP00000256429	DBD: Methyl-CpG DNA-binding	Other: MBD_C
Protein: ENSP00000464554	DBD: Methyl-CpG DNA-binding	Other:
Protein: ENSP00000381435	DBD: Methyl-CpG DNA-binding	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Regulatory Activity heterochromatin interaction/binding DNA-Binding non-sequence-specific_Non-specific DNA Other_ PMIDS:10471499 14610093
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	x
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Misc	HocoMoco		Direct

Structure

Structure	PDB	2KY8

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for MBD2 (MBD)