TF Info Page for TERF2 (Myb/SANT)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro The sequence in the crystal structure (PDB:1VFC), GTTAGGGTTAGGG, matches the inferred mouse motif.

Description

Description: telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729]
Entrez Summary This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000132604
External Link: CisBP
Interpro IPR001005; IPR009057; IPR013867; IPR017357; IPR017930; ;
Protein Domain: ENSP00000254942
Protein Domain: ENSP00000454955
Protein Domain: ENSP00000456022
Protein Domain: ENSP00000475507
Protein Domain: ENSP00000463079
Domain:
Protein: ENSP00000254942DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: TERF2_RBM, TRF
Protein: ENSP00000454955DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: PCI, TRF
Protein: ENSP00000456022DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: PCI, TERF2_RBM, TRF
Protein: ENSP00000475507DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: TERF2_RBM, TRF
Protein: ENSP00000463079DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - Terf2 (91% AA Identity, Mus musculus)

Structure

Structure PDB 1VFC

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution