The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Inferred motif	1 Monomer or homomultimer	High-throughput in vitro		The sequence in the crystal structure (PDB:1VFC), GTTAGGGTTAGGG, matches the inferred mouse motif.

Description

Description:	telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729]
Entrez Summary	TBA
Ensembl ID:	ENSG00000132604
External Link:
Interpro	IPR001005; IPR009057; IPR013867; IPR017357; IPR017930; ;
Protein Domain:
Protein: ENSP00000254942	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: TERF2_RBM, TRF
Protein: ENSP00000454955	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: PCI, TRF
Protein: ENSP00000456022	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: PCI, TERF2_RBM, TRF
Protein: ENSP00000475507	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: TERF2_RBM, TRF
Protein: ENSP00000463079	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	c
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
PBM	Zoo_01		Inferred - Terf2 (91% AA Identity, Mus musculus)

Structure

Structure	PDB	1VFC

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "straight", "end": 285, "endStyle": "straight", "aliStart": 95, "text": "TRF", "colour": "#9999ff", "aliEnd": 279, "start": 94, "href": "http://pfam.xfam.org/family/PF08558.8", "type": "pfama", "display": "true", "metadata": {"end": 285, "description": "Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain Pfam:PF00249 at the carboxy terminus [1]. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection [1]. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres [2]. This domain is composed of multiple alpha helices [3] arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors [4].", "database": "PfamA", "aliStart": 95, "scoreName": "E-value", "accession": "PF08558.8", "start": 94, "score": 2.5999999999999995e-35, "identifier": "Telomere repeat binding factor (TRF)", "type": "DBD", "aliEnd": 279}}, {"startStyle": "straight", "end": 278, "endStyle": "jagged", "aliStart": 205, "text": "PCI", "colour": "#9999ff", "aliEnd": 262, "start": 202, "href": "http://pfam.xfam.org/family/PF01399.25", "type": "pfama", "display": "true", "metadata": {"end": 278, "description": "This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].", "database": "PfamA", "aliStart": 205, "scoreName": "E-value", "accession": "PF01399.25", "start": 202, "score": 0.0093, "identifier": "PCI domain", "type": "DBD", "aliEnd": 262}}], "length": 294}

{"regions": [{"startStyle": "jagged", "end": 172, "endStyle": "straight", "aliStart": 3, "text": "TRF", "colour": "#9999ff", "aliEnd": 169, "start": 1, "href": "http://pfam.xfam.org/family/PF08558.8", "type": "pfama", "display": "true", "metadata": {"end": 172, "description": "Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain Pfam:PF00249 at the carboxy terminus [1]. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection [1]. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres [2]. This domain is composed of multiple alpha helices [3] arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors [4].", "database": "PfamA", "aliStart": 3, "scoreName": "E-value", "accession": "PF08558.8", "start": 1, "score": 7.7e-28, "identifier": "Telomere repeat binding factor (TRF)", "type": "DBD", "aliEnd": 169}}, {"startStyle": "straight", "end": 237, "endStyle": "straight", "aliStart": 198, "text": "TERF2_RBM", "colour": "#9999ff", "aliEnd": 237, "start": 197, "href": "http://pfam.xfam.org/family/PF16772.3", "type": "pfama", "display": "true", "metadata": {"end": 237, "description": "This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1) [1].", "database": "PfamA", "aliStart": 198, "scoreName": "E-value", "accession": "PF16772.3", "start": 197, "score": 7.4e-20, "identifier": "Telomeric repeat-binding factor 2 Rap1-binding motif", "type": "DBD", "aliEnd": 237}}, {"startStyle": "straight", "end": 165, "endStyle": "jagged", "aliStart": 84, "text": "PCI", "colour": "#9999ff", "aliEnd": 160, "start": 81, "href": "http://pfam.xfam.org/family/PF01399.25", "type": "pfama", "display": "true", "metadata": {"end": 165, "description": "This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].", "database": "PfamA", "aliStart": 84, "scoreName": "E-value", "accession": "PF01399.25", "start": 81, "score": 0.0058, "identifier": "PCI domain", "type": "DBD", "aliEnd": 160}}], "length": 283}

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TF Info Page for TERF2 (Myb/SANT)