lin-28 homolog A [Source:HGNC Symbol;Acc:HGNC:15986]
Entrez Summary
This gene encodes a LIN-28 family RNA-binding protein that acts as
a posttranscriptional regulator of genes involved in developmental timing and
self-renewal in embryonic stem cells. The encoded protein functions through
direct interaction with target mRNAs and by disrupting the maturation of
certain miRNAs involved in embryonic development. This protein prevents the
terminal processing of the LET7 family of microRNAs which are major
regulators of cellular growth and differentiation. Aberrant expression of
this gene is associated with cancer progression in multiple tissues.
[provided by RefSeq, Sep 2015]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF