TF Info Page for NR1H2 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 2 Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Likely an obligate heteromer (PMID: 7935418; PMID: 7892230; PMID: 7744246)

Description

Description: nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol;Acc:HGNC:7965]
Entrez Summary The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Ensembl ID: ENSG00000131408
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR008946; IPR023257; ;
Protein Domain: ENSP00000253727
Protein Domain: ENSP00000396151
Protein Domain: ENSP00000469778
Protein Domain: ENSP00000470518
Protein Domain: ENSP00000472138
Protein Domain: ENSP00000473099
Domain:
Protein: ENSP00000253727DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000396151DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000469778DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000470518DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000472138DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000473099DBD: Nuclear Hormone ReceptorOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:16007255 17218271
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:9013544
GO:0001133
sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor
IEA - GO_REF:0000019
GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
MiscHocoMocoDirect
MiscHOMERInferred - Nr1h2 (94% AA Identity, Mus musculus)

Structure

Structure PDB 4NQA

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution