The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	nuclear factor of activated T-cells 1 [Source:HGNC Symbol;Acc:HGNC:7775]
Entrez Summary	TBA
Ensembl ID:	ENSG00000131196
External Link:	T138171_1.02
Interpro	IPR002909; IPR008366; IPR008967; IPR011539; IPR014756; ;
Protein Domain:
Protein: ENSP00000253506	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000316553	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000327850	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000380892	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000389377	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000442435	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000466489	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000468111	DBD: RHD	Other:
Protein: ENSP00000466194	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000467181	DBD: RHD	Other: RHD_dimer, TIG
Protein: ENSP00000439992	DBD: RHD	Other: RHD_dimer, TIG

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding TF PPI Transactivation_ PMIDS:15117818 16109714
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv ISS - GO_REF:0000024 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10821850, PMID:9506523 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS - GO_REF:0000024
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2010		Direct
HT-SELEX	Jolma2010		Direct
HT-SELEX	Jolma2010		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct
PBM	Zoo_01		Inferred - NFATC1 (95% AA Identity, Meleagris gallopavo)
PBM	Zoo_01		Inferred - NFATC1 (95% AA Identity, Monodelphis domestica)
PBM	Zoo_01		Inferred - nfatc1 (93% AA Identity, Xenopus tropicalis)
HT-SELEX	Yin2017		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
COMPILED	JASPAR		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC2 (83% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC2 (83% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC3 (81% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC3 (81% AA Identity, Homo sapiens)
PBM	TF_Evolution	Unpublished Data	Inferred - NFATC4 (78% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC4 (78% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - NFATC4 (78% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - NFATC4 (78% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - NFATC2 (75% AA Identity, Tetraodon nigroviridis)

Structure

Structure	PDB	1A66

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for NFATC1 (Rel)