DNA (cytosine-5-)-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976]
Entrez Summary
This gene encodes an enzyme that transfers methyl groups to
cytosine nucleotides of genomic DNA. This protein is the major enzyme
responsible for maintaining methylation patterns following DNA replication
and shows a preference for hemi-methylated DNA. Methylation of DNA is an
important component of mammalian epigenetic gene regulation. Aberrant
methylation patterns are found in human tumors and associated with
developmental abnormalities. Variation in this gene has been associated with
cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary
sensory, type IE. Alternative splicing results in multiple transcript
variants. [provided by RefSeq, Jan 2016]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF