TF Info Page for NPAS1 (bHLH)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Inferred motif | 2 Obligate heteromer | In vivo/Misc source | Likely obligate heteromer (PMID: 27782878). |
Description
| Description: | neuronal PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:7894] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000130751 | |
| External Link: | T014204_1.02 | |
| Interpro | IPR000014; IPR011598; IPR013655; IPR013767; | |
| Protein Domain: | ||
| Protein: ENSP00000405290 | DBD: bHLH | Other: PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000469142 | DBD: bHLH | Other: PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000398689 | DBD: bHLH | Other: PAS_11, PAS_3 |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding non-sequence-specific_Non-specific DNA_ PMIDS:15635607 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:9012850 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |