TF Info Page for GATA5 (GATA)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802]
Entrez Summary The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000130700
External Link: CisBP
Interpro IPR000679; IPR008013; IPR016375; ;
Protein Domain: ENSP00000252997
Domain:
Protein: ENSP00000252997DBD: GATAOther: GATA-N

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:10212267 11408257
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:14986113
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
PBMBadis09Inferred - Gata5 (95% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Gata5 (95% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - GATA4 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA4 (91% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Gata4 (91% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - GATA4 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA4 (91% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gata4 (91% AA Identity, Mus musculus)
MiscHocoMocoInferred - GATA4 (91% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata4 (91% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - GATA6 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA6 (87% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata6 (87% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - pnr (87% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - pnr (87% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - GATA6 (87% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA6 (87% AA Identity, Homo sapiens)
ChIP-chipJASPARInferred - pnr (87% AA Identity, Drosophila melanogaster)
ChIP-seqmodENCODEInferred - pnr (87% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - GATA6 (87% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - srp (84% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - srp (84% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - srp (84% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - GATA2 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA2 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA3 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA3 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (82% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata3 (82% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Gata3 (82% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - Gata1 (82% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA2 (82% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA3 (82% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - GATA3 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA2 (82% AA Identity, Homo sapiens)
MiscHOMERInferred - GATA2 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA3 (82% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata3 (82% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (82% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (82% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (82% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (82% AA Identity, Mus musculus)
HT-SELEXJolma2010Inferred - GATA1 (81% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - GATA1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA1 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (81% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (81% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA1 (81% AA Identity, Homo sapiens)
MiscHOMERInferred - GATA1 (81% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - elt-1 (74% AA Identity, Caenorhabditis elegans)
ChIP-seqmodENCODEInferred - elt-1 (74% AA Identity, Caenorhabditis elegans)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution