TF Info Page for JUND (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206]
Entrez Summary The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
Ensembl ID: ENSG00000130522
External Link: CisBP
Interpro IPR002112; IPR004827; IPR005643; IPR008917;
Protein Domain: ENSP00000475153
Protein Domain: ENSP00000252818
Domain:
Protein: ENSP00000475153DBD: bZIPOther: Jun
Protein: ENSP00000252818DBD: bZIPOther: Jun

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:2504580
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
SMiLE-seqIsakova2017Direct
SMiLE-seqIsakova2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMMann2013Inferred - Jund (100% AA Identity, Mus musculus)
PBMMann2013Inferred - Jund (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - Jund (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - jund (93% AA Identity, Xenopus tropicalis)
SMiLE-seqIsakova2017Inferred - JUN (89% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - JUN (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JUN (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JUN (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JUN (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JUN (89% AA Identity, Homo sapiens)
PBMMann2013Inferred - Jun (89% AA Identity, Mus musculus)
PBMZoo_01Inferred - Jun (89% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - JUN (89% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - JUN (89% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - JUN (89% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - JUN (89% AA Identity, Homo sapiens)
MiscHocoMocoInferred - JUN (89% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - JUN_AVIS1 (87% AA Identity, Avian sarcoma virus 17)
SMiLE-seqIsakova2017Inferred - JUNB (81% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - JUNB (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - JUNB (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - JUNB (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - JUNB (81% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - JUNB (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - JUNB (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - JUNB (81% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Junb (79% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Jra (67% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution