Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description: | forkhead box A1 [Source:HGNC Symbol;Acc:HGNC:5021] | |||
Entrez Summary | #!usr/local/bin/perl ?> This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008] | |||
Ensembl ID: | ENSG00000129514 | |||
External Link: | CisBP | |||
Interpro | IPR001766; IPR013638; IPR018122; IPR018533; | |||
Protein Domain: | ENSP00000250448 | |||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:2227418 11864602 15485926 15539431 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a ISS - GO_REF:0000024 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8652662 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP - PMID:16087863 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |