TF Info Page for E2F8 (E2F)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727]
Entrez Summary This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Ensembl ID: ENSG00000129173
External Link: CisBP
Interpro IPR003316; ;
Protein Domain: ENSP00000250024
Protein Domain: ENSP00000437326
Protein Domain: ENSP00000434199
Protein Domain: ENSP00000481103
Domain:
Protein: ENSP00000250024DBD: E2FOther:
Protein: ENSP00000437326DBD: E2FOther:
Protein: ENSP00000434199DBD: E2FOther:
Protein: ENSP00000481103DBD: E2FOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:16179649
GO:0003700
sequence-specific DNA binding transcription factor activity
IMP - PMID:22903062
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
HT-SELEXYin2017Inferred - E2F7 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - E2F7 (75% AA Identity, Homo sapiens)
MiscHocoMocoInferred - E2F7 (75% AA Identity, Homo sapiens)
MiscHOMERInferred - E2F7 (75% AA Identity, Homo sapiens)

Structure

Structure PDB 4YO2

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution