methyl-CpG binding domain 4, DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:6919]
Entrez Summary
The protein encoded by this gene is a member of a family of nuclear
proteins related by the presence of a methyl-CpG binding domain (MBD). These
proteins are capable of binding specifically to methylated DNA, and some
members can also repress transcription from methylated gene promoters. This
protein contains an MBD domain at the N-terminus that functions both in
binding to methylated DNA and in protein interactions and a C-terminal
mismatch-specific glycosylase domain that is involved in DNA repair.
Alternatively spliced transcript variants encoding multiple isoforms have
been observed for this gene. [provided by RefSeq, Jan 2013]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF