The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	homeobox D9 [Source:HGNC Symbol;Acc:HGNC:5140]
Entrez Summary	TBA
Ensembl ID:	ENSG00000128709
External Link:	T093297_1.02
Interpro	IPR001356; IPR006711; IPR009057; IPR017112; IPR017970; IPR020479;
Protein Domain:
Protein: ENSP00000249499	DBD: Homeodomain	Other: Hox9_act

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8890171
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:1756725
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
ChIP-seq	JASPAR		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
Misc	HOMER		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb9 (94% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa10 (82% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc10 (82% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd10 (82% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Hoxa10 (82% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
PBM	BusserDevelopment2012		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb8 (75% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc8 (75% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa6 (73% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd8 (73% AA Identity, Mus musculus)
B1H	JASPAR		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Antp (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa7 (71% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa7 (71% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb6 (71% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc6 (71% AA Identity, Mus musculus)
B1H	JASPAR		Inferred - Scr (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Scr (71% AA Identity, Drosophila melanogaster)
PBM	BusserDevelopment2012		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Antp (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - Antp (71% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC6 (71% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa5 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb5 (70% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb7 (70% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc5 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD11 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD11 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd11 (70% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Q0N4M8_NEMVE (70% AA Identity, Nematostella vectensis)
COMPILED	JASPAR		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa11 (68% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA4 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa4 (68% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
PBM	Barrera2016		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA4 (68% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - lin-39 (68% AA Identity, Caenorhabditis elegans)
Misc	HOMER		Inferred - lin-39 (68% AA Identity, Caenorhabditis elegans)
B1H	JASPAR		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
PBM	Badis09		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc11 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd3 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
B1H	JASPAR		Inferred - pb (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - pb (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Pdx1 (66% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ftz (66% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA3 (66% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
Misc	HOMER		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Pdx1 (66% AA Identity, Mus musculus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

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Comment
Reference

{"regions": [{"startStyle": "curved", "end": 342, "endStyle": "curved", "aliStart": 286, "text": "HD", "colour": "#228B22", "aliEnd": 342, "start": 286, "href": "http://pfam.xfam.org/family/PF00046.27", "type": "pfama", "display": "true", "metadata": {"end": 342, "description": "The homeobox domain or homeodomain was first identified in a number of drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [PUBMED:2568852, PUBMED:1357790]. Hox genes encode homeodomain-containing transcriptional regulators that operate differential genetic programs along the anterior-posterior axis of animal bodies [PUBMED:12445403]. The domain binds DNA through a helix-turn-helix (HTH) structure. ", "database": "PfamA", "aliStart": 286, "scoreName": "E-value", "accession": "PF00046.27", "start": 286, "score": 2.4e-20, "identifier": "Homeobox domain", "type": "DBD", "aliEnd": 342}}, {"startStyle": "straight", "end": 216, "endStyle": "jagged", "aliStart": 11, "text": "Hox9_act", "colour": "#9999ff", "aliEnd": 200, "start": 11, "href": "http://pfam.xfam.org/family/PF04617.11", "type": "pfama", "display": "true", "metadata": {"end": 216, "description": "This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].", "database": "PfamA", "aliStart": 11, "scoreName": "E-value", "accession": "PF04617.11", "start": 11, "score": 9.2e-50, "identifier": "Hox9 activation region    ", "type": "DBD", "aliEnd": 200}}, {"startStyle": "jagged", "end": 274, "endStyle": "straight", "aliStart": 215, "text": "Hox9_act", "colour": "#9999ff", "aliEnd": 271, "start": 208, "href": "http://pfam.xfam.org/family/PF04617.11", "type": "pfama", "display": "true", "metadata": {"end": 274, "description": "This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].", "database": "PfamA", "aliStart": 215, "scoreName": "E-value", "accession": "PF04617.11", "start": 208, "score": 9.2e-50, "identifier": "Hox9 activation region    ", "type": "DBD", "aliEnd": 271}}], "length": 353}

TF Info Page for HOXD9 (Homeodomain)