The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

homeobox D9 [Source:HGNC Symbol;Acc:HGNC:5140]

Entrez Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]

Ensembl ID:

ENSG00000128709

External Link:

CisBP

Interpro

IPR001356; IPR006711; IPR009057; IPR017112; IPR017970; IPR020479;

Protein Domain:

ENSP00000249499

Domain:

Protein: ENSP00000249499	DBD: Homeodomain	Other: Hox9_act

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8890171
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:1756725
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (98% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (96% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
ChIP-seq	JASPAR		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA9 (96% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Hoxa9 (96% AA Identity, Mus musculus)
Misc	HOMER		Inferred - Hoxc9 (96% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB9 (94% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb9 (94% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa10 (82% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc10 (82% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd10 (82% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Hoxa10 (82% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXD10 (82% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXD10 (82% AA Identity, Homo sapiens)
PBM	BusserDevelopment2012		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb8 (75% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc8 (75% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXC8 (75% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Abd-B (75% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXB8 (75% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC8 (75% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa6 (73% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd8 (73% AA Identity, Mus musculus)
B1H	JASPAR		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Antp (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa7 (71% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa7 (71% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb6 (71% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc6 (71% AA Identity, Mus musculus)
B1H	JASPAR		Inferred - Scr (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Scr (71% AA Identity, Drosophila melanogaster)
PBM	BusserDevelopment2012		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Antp (71% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - abd-A (71% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - Antp (71% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXA7 (71% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXB6 (71% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC6 (71% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Ubx (71% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa5 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb5 (70% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb7 (70% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc5 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD11 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD11 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd11 (70% AA Identity, Mus musculus)
PBM	Zoo_01		Inferred - Q0N4M8_NEMVE (70% AA Identity, Nematostella vectensis)
COMPILED	JASPAR		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA5 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXB7 (70% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa11 (68% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA4 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa4 (68% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
PBM	Barrera2016		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA4 (68% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - lin-39 (68% AA Identity, Caenorhabditis elegans)
Misc	HOMER		Inferred - lin-39 (68% AA Identity, Caenorhabditis elegans)
B1H	JASPAR		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
PBM	Badis09		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC11 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc11 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd3 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
B1H	JASPAR		Inferred - pb (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - pb (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - PDX1 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Pdx1 (66% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ftz (66% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA3 (66% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - PDX1 (66% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - ftz (66% AA Identity, Drosophila melanogaster)
Misc	HOMER		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - HOXD4 (66% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - PDX1 (66% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Pdx1 (66% AA Identity, Mus musculus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

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Comment
Reference

{"regions": [{"startStyle": "curved", "end": 342, "endStyle": "curved", "aliStart": 286, "text": "HD", "colour": "#228B22", "aliEnd": 342, "start": 286, "href": "http://pfam.xfam.org/family/PF00046.27", "type": "pfama", "display": "true", "metadata": {"end": 342, "description": "The homeobox domain or homeodomain was first identified in a number of drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [PUBMED:2568852, PUBMED:1357790]. Hox genes encode homeodomain-containing transcriptional regulators that operate differential genetic programs along the anterior-posterior axis of animal bodies [PUBMED:12445403]. The domain binds DNA through a helix-turn-helix (HTH) structure. ", "database": "PfamA", "aliStart": 286, "scoreName": "E-value", "accession": "PF00046.27", "start": 286, "score": 2.4e-20, "identifier": "Homeobox domain", "type": "DBD", "aliEnd": 342}}, {"startStyle": "straight", "end": 216, "endStyle": "jagged", "aliStart": 11, "text": "Hox9_act", "colour": "#9999ff", "aliEnd": 200, "start": 11, "href": "http://pfam.xfam.org/family/PF04617.11", "type": "pfama", "display": "true", "metadata": {"end": 216, "description": "This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].", "database": "PfamA", "aliStart": 11, "scoreName": "E-value", "accession": "PF04617.11", "start": 11, "score": 9.2e-50, "identifier": "Hox9 activation region    ", "type": "DBD", "aliEnd": 200}}, {"startStyle": "jagged", "end": 274, "endStyle": "straight", "aliStart": 215, "text": "Hox9_act", "colour": "#9999ff", "aliEnd": 271, "start": 208, "href": "http://pfam.xfam.org/family/PF04617.11", "type": "pfama", "display": "true", "metadata": {"end": 274, "description": "This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].", "database": "PfamA", "aliStart": 215, "scoreName": "E-value", "accession": "PF04617.11", "start": 208, "score": 9.2e-50, "identifier": "Hox9 activation region    ", "type": "DBD", "aliEnd": 271}}], "length": 353}

TF Info Page for HOXD9 (Homeodomain)