TF Info Page for FOXP2 (Forkhead)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: forkhead box P2 [Source:HGNC Symbol;Acc:HGNC:13875]
Entrez Summary This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Ensembl ID: ENSG00000128573
External Link: CisBP
Interpro IPR001766; ;
Protein Domain: ENSP00000265436
Protein Domain: ENSP00000353367
Protein Domain: ENSP00000367482
Protein Domain: ENSP00000375084
Protein Domain: ENSP00000377129
Protein Domain: ENSP00000386200
Protein Domain: ENSP00000418100
Protein Domain: ENSP00000385069
Protein: ENSP00000265436DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000353367DBD: ForkheadOther: FOXP-CC
Protein: ENSP00000367482DBD: ForkheadOther: CDC45, FOXP-CC
Protein: ENSP00000375084DBD: ForkheadOther: CDC45, FOXP-CC
Protein: ENSP00000377129DBD: ForkheadOther: CDC45, FOXP-CC
Protein: ENSP00000386200DBD: ForkheadOther: CDC45, FOXP-CC
Protein: ENSP00000418100DBD: ForkheadOther:
Protein: ENSP00000385069DBD: ForkheadOther: CDC45, FOXP-CC

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
PMIDS:11358962 14701752 11358962 14701752
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
sequence-specific DNA binding transcription factor activity
IDA - PMID:18987363
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMDREAM_contestInferred - Foxp2 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - FOXP1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXP1 (88% AA Identity, Homo sapiens)
PBMZoo_01Inferred - FOXP1 (88% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Foxp1 (88% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - FOXP1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXP1 (88% AA Identity, Homo sapiens)
MiscHOMERInferred - FOXP1 (88% AA Identity, Homo sapiens)


Structure PDB 2A07

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution