TF Info Page for FOXP2 (Forkhead)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | forkhead box P2 [Source:HGNC Symbol;Acc:HGNC:13875] | ||||||||||||||||||||||||
| Entrez Summary | This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] | ||||||||||||||||||||||||
| Ensembl ID: | ENSG00000128573 | ||||||||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||||||||
| Interpro | IPR001766; ; | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000265436 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000353367 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000367482 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000375084 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000377129 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000386200 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000418100 | ||||||||||||||||||||||||
| Protein Domain: | ENSP00000385069 | ||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Transactivation_ PMIDS:11358962 14701752 11358962 14701752 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:18987363 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |