zinc finger protein 384 [Source:HGNC Symbol;Acc:HGNC:11955]
Entrez Summary
This gene encodes a C2H2-type zinc finger protein, which may
function as a transcription factor. This gene also contains long CAG
trinucleotide repeats that encode consecutive glutamine residues. The protein
appears to bind and regulate the promoters of the extracellular matrix genes
MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix
transcription factors (NP/NMP4) may be part of a general mechanical pathway
that couples cell construction and function during extracellular matrix
remodeling. Alternative splicing results in multiple transcript variants.
Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on
chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3
(E2A) gene on chromosome 19, have been observed in acute leukemia. A related
pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF