Related to DACH1, which can bind DNA based on EMSA and SELEX (PMID: 20351289). Yet, the fly ortholog has been extensively studied and cannot bind DNA. (PMID: 8431945; PMID: 7821215)
Description
Description:
Dachshund family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:16814]
Entrez Summary
This gene is one of two genes which encode a protein similar to the
Drosophila protein dachshund, a transcription factor involved in cell fate
determination in the eye, limb and genital disc of the fly. The encoded
protein contains two characteristic dachshund domains: an N-terminal domain
responsible for DNA binding and a C-terminal domain responsible for
protein-protein interactions. This gene is located on the X chromosome and is
subject to inactivation by DNA methylation. The encoded protein may be
involved in regulation of organogenesis and myogenesis, and may play a role
in premature ovarian failure. Multiple transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001075 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF