The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118]
Entrez Summary	TBA
Ensembl ID:	ENSG00000126456
External Link:
Interpro	IPR001346; IPR008984; IPR019471; IPR019817;
Protein Domain:
Protein: ENSP00000310127	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000366339	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000366344	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000400378	DBD: Interferon regulatory factor (IRF)	Other:
Protein: ENSP00000472601	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000470512	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000470069	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000471358	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000472700	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000471896	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000471517	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000469113	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000471402	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000470140	DBD: Interferon regulatory factor (IRF)	Other:
Protein: ENSP00000473176	DBD: Interferon regulatory factor (IRF)	Other:
Protein: ENSP00000469067	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000468911	DBD: Interferon regulatory factor (IRF)	Other:
Protein: ENSP00000472223	DBD: Interferon regulatory factor (IRF)	Other: IRF-3
Protein: ENSP00000470905	DBD: Interferon regulatory factor (IRF)	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:9660935
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	Badis09		Inferred - Irf3 (85% AA Identity, Mus musculus)

Structure

Structure	PDB	2O6G

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for IRF3 (IRF)