TF Info Page for THRA (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Likely binds as a heterodimer too |
Description
| Description: | thyroid hormone receptor, alpha [Source:HGNC Symbol;Acc:HGNC:11796] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000126351 | |
| External Link: | ||
| Interpro | IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ; | |
| Protein Domain: | ||
| Protein: ENSP00000264637 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000395641 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000463466 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000377679 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000443972 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_Co-activation DNA Binding_ PMIDS:8559662 11773435 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:18052923, PMID:8710870, PMID:9653119 GO:0004887 thyroid hormone receptor activity IDA - PMID:15466465, PMID:18052923, PMID:8710870 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |