TF Info Page for THRA (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Likely binds as a heterodimer too

Description

Description: thyroid hormone receptor, alpha [Source:HGNC Symbol;Acc:HGNC:11796]
Entrez Summary The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000126351
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ;
Protein Domain: ENSP00000264637
Protein Domain: ENSP00000395641
Protein Domain: ENSP00000463466
Protein Domain: ENSP00000377679
Protein Domain: ENSP00000443972
Domain:
Protein: ENSP00000264637DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000395641DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000463466DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000377679DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000443972DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_Co-activation
DNA Binding_
PMIDS:8559662 11773435
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:18052923, PMID:8710870, PMID:9653119
GO:0004887
thyroid hormone receptor activity
IDA - PMID:15466465, PMID:18052923, PMID:8710870
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHocoMocoDirect
MiscHOMERInferred - Thra (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - GAG_AVIER (94% AA Identity, Avian erythroblastosis virus)
HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - THRB (87% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - THRB (87% AA Identity, Homo sapiens)
MiscHocoMocoInferred - THRB (87% AA Identity, Homo sapiens)
MiscHocoMocoInferred - THRB (87% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution