TF Info Page for TCF15 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: transcription factor 15 (basic helix-loop-helix) [Source:HGNC Symbol;Acc:HGNC:11627]
Entrez Summary The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000125878
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000246080
Domain:
Protein: ENSP00000246080DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
non-sequence-specific_DNA Binding_
PMIDS:7597044
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8041747, PMID:8825648
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Msc (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Tcf21 (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HAND2 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HAND2 (55% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Twist2 (55% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - TWIST1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TWIST1 (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TWIST1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHOMERInferred - Tal1 (53% AA Identity, Mus musculus)
MiscHOMERInferred - Tal1 (53% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ATOH7 (52% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH7 (52% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - twi (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - twi (51% AA Identity, Drosophila melanogaster)
DNaseI footprintingJASPARInferred - twi (51% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - twi (51% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - twi (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Fer1 (50% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution