TF Info Page for TCF15 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: transcription factor 15 (basic helix-loop-helix) [Source:HGNC Symbol;Acc:HGNC:11627]
Entrez Summary NA
Ensembl ID: ENSG00000125878
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000246080
Domain:
Protein: ENSP00000246080DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
non-sequence-specific_DNA Binding_
PMIDS:7597044
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:8041747, PMID:8825648
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (60% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Msc (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (60% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Tcf21 (60% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HAND2 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HAND2 (55% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Twist2 (55% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - TWIST1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TWIST1 (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TWIST1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (53% AA Identity, Homo sapiens)
MiscHOMERInferred - Tal1 (53% AA Identity, Mus musculus)
MiscHOMERInferred - Tal1 (53% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ATOH7 (52% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH7 (52% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - twi (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - twi (51% AA Identity, Drosophila melanogaster)
DNaseI footprintingJASPARInferred - twi (51% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - twi (51% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - twi (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Fer1 (50% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution