TF Info Page for RBCK1 (Unknown)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Fairly well-studied E3 ubiquitin-protein ligase. But EMSA data exist demonstrating binding to TGG-containing DNA (PMID: 9514928)

Description

Description: RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol;Acc:HGNC:15864]
Entrez Summary The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000125826
External Link: CisBP
Interpro IPR000626; IPR001841; IPR001876; IPR002867; IPR017907; IPR029071;
Protein Domain: ENSP00000254960
Protein Domain: ENSP00000348632
Protein Domain: ENSP00000371616
Protein Domain: ENSP00000417173
Protein Domain: ENSP00000383106
Protein Domain: ENSP00000415080
Protein Domain: ENSP00000393841
Domain:
Protein: ENSP00000254960DBD: OtherOther: IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11
Protein: ENSP00000348632DBD: OtherOther: IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11
Protein: ENSP00000371616DBD: OtherOther: IBR
Protein: ENSP00000417173DBD: OtherOther:
Protein: ENSP00000383106DBD: OtherOther:
Protein: ENSP00000415080DBD: OtherOther: ubiquitin
Protein: ENSP00000393841DBD: OtherOther: ubiquitin, zf-RanBP

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF? No
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0032088
negative regulation of NF-kappaB transcription factor activity
IDA - PMID:17449468
GO:0051092
positive regulation of NF-kappaB transcription factor activity
IDA - PMID:19136968
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution