TF Info Page for RBCK1 (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Fairly well-studied E3 ubiquitin-protein ligase. But EMSA data exist demonstrating binding to TGG-containing DNA (PMID: 9514928) |
Description
| Description: | RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol;Acc:HGNC:15864] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000125826 | |
| External Link: | ||
| Interpro | IPR000626; IPR001841; IPR001876; IPR002867; IPR017907; IPR029071; | |
| Protein Domain: | ||
| Protein: ENSP00000254960 | DBD: Other | Other: IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11 |
| Protein: ENSP00000348632 | DBD: Other | Other: IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11 |
| Protein: ENSP00000371616 | DBD: Other | Other: IBR |
| Protein: ENSP00000417173 | DBD: Other | Other: |
| Protein: ENSP00000383106 | DBD: Other | Other: |
| Protein: ENSP00000415080 | DBD: Other | Other: ubiquitin |
| Protein: ENSP00000393841 | DBD: Other | Other: ubiquitin, zf-RanBP |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA - PMID:17449468 GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA - PMID:19136968 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
5a, one of the source datasets predicts is as a TF |
| TF has conditional DNA-binding requirements |