centromere protein B [Source:HGNC Symbol;Acc:HGNC:1852]
Entrez Summary
This gene product is a highly conserved protein that facilitates
centromere formation. It is a DNA-binding protein that is derived from
transposases of the pogo DNA transposon family. It contains a
helix-loop-helix DNA binding motif at the N-terminus, and a dimerization
domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp
sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is
proposed to play an important role in the assembly of specific centromere
structures in interphase nuclei and on mitotic chromosomes. It is also
considered a major centromere autoantigen recognized by sera from patients
with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF