TF Info Page for GZF1 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: GDNF inducible zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:15808]
Entrez Summary NA
Ensembl ID: ENSG00000125812
External Link: CisBP
Interpro IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain: ENSP00000338290
Protein Domain: ENSP00000366250
Protein Domain: ENSP00000410009
Domain:
Protein: ENSP00000338290DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met
Protein: ENSP00000366250DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met
Protein: ENSP00000410009DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:16049025 | IMP - PMID:16049025
GO:0001206
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv
IDA - PMID:16049025 | IMP - PMID:16049025
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution