Only known motifs are from Transfac or HocoMoco - origin is uncertain
Description
Description:
GDNF inducible zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:15808]
Entrez Summary
Enables DNA-binding transcription repressor activity, RNA
polymerase II-specific and RNA polymerase II cis-regulatory region
sequence-specific DNA binding activity. Involved in negative regulation of
transcription by RNA polymerase II. Located in nucleolus and nucleoplasm.
[provided by Alliance of Genome Resources, Apr 2022]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16049025 | IMP - PMID:16049025 GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IDA - PMID:16049025 | IMP - PMID:16049025
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF