TF Info Page for FOSB (bZIP)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | FosB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3797] | |||||||||||||||||||||||||||
| Entrez Summary | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | |||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000125740 | |||||||||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||||||||
| Interpro | IPR000837; IPR004827; | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000245919 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000407207 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000414177 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000467497 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000468207 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000465068 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000466530 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000485018 | |||||||||||||||||||||||||||
| Protein Domain: | ENSP00000468482 | |||||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Factor Binding tf co-factor binding_TF PPI_ PMIDS:2498083 14515349 16699069 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |