TF Info Page for TTF1 (Myb/SANT)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Contains Myb and Myb-like domains, and is annotated as a Pol1 terminator. DNA-binding has been demonstrated in vitro via EMSA (PMID: 7597036). |
Description
| Description: | transcription termination factor 1 [Source:HGNC Symbol;Acc:HGNC:12397] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000125482 | |
| External Link: | T118152_1.02 | |
| Interpro | IPR001005; IPR017877; | |
| Protein Domain: | ||
| Protein: ENSP00000333920 | DBD: Myb, Myb-Like, and SANT Domain Containing Genes | Other: |
| Protein: ENSP00000481441 | DBD: Myb, Myb-Like, and SANT Domain Containing Genes | Other: Myb_DNA-bind_6 |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:7720715 9049305 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
| TF has conditional DNA-binding requirements |