Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
In vivo/Misc source
Description
Description:
interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116]
Entrez Summary
TBA
Ensembl ID:
ENSG00000125347
External Link:
T107581_1.02
Interpro
IPR001346 ; IPR017431 ; IPR019817 ; ;
Protein Domain:
Protein: ENSP00000245414DBD: Interferon regulatory factor (IRF)Other: Protein: ENSP00000480887DBD: Interferon regulatory factor (IRF)Other: Protein: ENSP00000473661DBD: Interferon regulatory factor (IRF)Other: Protein: ENSP00000405655DBD: Interferon regulatory factor (IRF)Other:
Previous Annotations
Source
Annotation
TF-CAT classification
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:3409321 12517966
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IMP - PMID:15509808
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "curved", "end": 112, "endStyle": "curved", "aliStart": 7, "text": "IRF", "colour": "#009900", "aliEnd": 111, "start": 7, "href": "http://pfam.xfam.org/family/PF00605.15", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.", "database": "PfamA", "aliStart": 7, "scoreName": "E-value", "accession": "PF00605.15", "start": 7, "score": 3.5999999999999996e-41, "identifier": "Interferon regulatory factor transcription factor", "type": "DBD", "aliEnd": 111}}], "length": 326}
{"regions": [{"startStyle": "curved", "end": 112, "endStyle": "curved", "aliStart": 7, "text": "IRF", "colour": "#009900", "aliEnd": 111, "start": 7, "href": "http://pfam.xfam.org/family/PF00605.15", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.", "database": "PfamA", "aliStart": 7, "scoreName": "E-value", "accession": "PF00605.15", "start": 7, "score": 1.1999999999999999e-41, "identifier": "Interferon regulatory factor transcription factor", "type": "DBD", "aliEnd": 111}}], "length": 202}
{"regions": [{"startStyle": "curved", "end": 112, "endStyle": "curved", "aliStart": 7, "text": "IRF", "colour": "#009900", "aliEnd": 111, "start": 7, "href": "http://pfam.xfam.org/family/PF00605.15", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.", "database": "PfamA", "aliStart": 7, "scoreName": "E-value", "accession": "PF00605.15", "start": 7, "score": 3.2999999999999996e-42, "identifier": "Interferon regulatory factor transcription factor", "type": "DBD", "aliEnd": 111}}], "length": 118}
{"regions": [{"startStyle": "curved", "end": 112, "endStyle": "curved", "aliStart": 7, "text": "IRF", "colour": "#009900", "aliEnd": 111, "start": 7, "href": "http://pfam.xfam.org/family/PF00605.15", "type": "pfama", "display": "true", "metadata": {"end": 112, "description": "This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.", "database": "PfamA", "aliStart": 7, "scoreName": "E-value", "accession": "PF00605.15", "start": 7, "score": 1.0999999999999999e-41, "identifier": "Interferon regulatory factor transcription factor", "type": "DBD", "aliEnd": 111}}], "length": 198}