TF Info Page for IRF1 (IRF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116]
Entrez Summary The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
Ensembl ID: ENSG00000125347
External Link: CisBP
Interpro IPR001346; IPR017431; IPR019817; ;
Protein Domain: ENSP00000245414
Protein Domain: ENSP00000480887
Protein Domain: ENSP00000473661
Protein Domain: ENSP00000405655
Domain:
Protein: ENSP00000245414DBD: Interferon regulatory factor (IRF)Other:
Protein: ENSP00000480887DBD: Interferon regulatory factor (IRF)Other:
Protein: ENSP00000473661DBD: Interferon regulatory factor (IRF)Other:
Protein: ENSP00000405655DBD: Interferon regulatory factor (IRF)Other:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:3409321 12517966
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IMP - PMID:15509808
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
HT-SELEXYin2017Inferred - IRF2 (76% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - IRF2 (76% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Irf2 (76% AA Identity, Mus musculus)
SELEXJASPARInferred - IRF2 (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IRF2 (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IRF2 (76% AA Identity, Homo sapiens)
MiscHocoMocoInferred - IRF2 (76% AA Identity, Homo sapiens)
MiscHOMERInferred - IRF2 (76% AA Identity, Homo sapiens)

Structure

Structure PDB 1IF1

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution