Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
High-throughput in vitro
Mouse ortholog binds a highly similar motif.
Description
Description:
myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181]
Entrez Summary
#!usr/local/bin/perl
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This gene encodes a transcription factor that is required for
central nervous system myelination and may regulate oligodendrocyte
differentiation. It is thought to act by increasing the expression of genes
that effect myelin production but may also directly promote myelin gene
expression. Loss of a similar gene in mouse models results in severe
demyelination. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Nov 2014]
Ensembl ID:
ENSG00000124920
External Link:
CisBP
Interpro
IPR008967 ; IPR024061 ; IPR025719 ; IPR026932 ; IPR030392 ; ;
Protein Domain:
ENSP00000265460
Protein Domain:
ENSP00000278836
Protein Domain:
ENSP00000374253
Domain:
Protein: ENSP00000265460DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74Protein: ENSP00000278836DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74Protein: ENSP00000374253DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
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