TF Info Page for MYRF (Ndt80/PhoG)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Mouse ortholog binds a highly similar motif.


Description: myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181]
Entrez Summary This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Ensembl ID: ENSG00000124920
External Link: CisBP
Interpro IPR008967; IPR024061; IPR025719; IPR026932; IPR030392; ;
Protein Domain: ENSP00000265460
Protein Domain: ENSP00000278836
Protein Domain: ENSP00000374253
Protein: ENSP00000265460DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74
Protein: ENSP00000278836DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74
Protein: ENSP00000374253DBD: OtherOther: MRF_C1, MRF_C2, Peptidase_S74

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - Myrf (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - myrf (84% AA Identity, Danio rerio)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution