TF Info Page for GCM2 (GCM)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: glial cells missing homolog 2 [Source:HGNC Symbol;Acc:HGNC:4198]
Entrez Summary This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000124827
External Link: CisBP
Interpro IPR003902; ;
Protein Domain: ENSP00000368805
Domain:
Protein: ENSP00000368805DBD: GCMOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:10671510
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
PBMZoo_01Inferred - GCM2 (86% AA Identity, Taeniopygia guttata)
PBMZoo_01Inferred - gcm2 (83% AA Identity, Takifugu rubripes)
PBMZoo_01Inferred - gcm2 (82% AA Identity, Tetraodon nigroviridis)
PBMBadis09Inferred - Gcm1 (71% AA Identity, Mus musculus)
PBMZoo_01Inferred - Gcm1 (71% AA Identity, Rattus norvegicus)
PBMZoo_01Inferred - XP_004449939.1 (70% AA Identity, Dasypus novemcinctus)
SMiLE-seqIsakova2017Inferred - GCM1 (69% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GCM1 (69% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GCM1 (69% AA Identity, Homo sapiens)
PBMZoo_01Inferred - GCM1 (69% AA Identity, Homo sapiens)
PBMZoo_01Inferred - GCM1 (69% AA Identity, Meleagris gallopavo)
TransfacTransfacLicense requiredInferred - GCM1 (69% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GCM1 (69% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GCM1 (69% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - gcm2 (67% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - gcm2 (67% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - gcm2 (67% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - gcm (65% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - gcm (65% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - gcm (65% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - gcm (65% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution