TF Info Page for HIF3A (bHLH)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Inferred motif | 2 Obligate heteromer | In vivo/Misc source | Binds DNA as a heterodimer with ARNT and ARNT2; reviewed in (PMID: 24099156). |
Description
| Description: | hypoxia inducible factor 3 alpha subunit [Source:HGNC Symbol;Acc:HGNC:15825] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000124440 | |
| External Link: | ||
| Interpro | IPR000014; IPR001610; IPR011598; IPR013767; IPR021537; ; | |
| Protein Domain: | ||
| Protein: ENSP00000300862 | DBD: bHLH | Other: HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000366898 | DBD: bHLH | Other: HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000244303 | DBD: bHLH | Other: HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000434653 | DBD: bHLH | Other: PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
| Protein: ENSP00000471560 | DBD: bHLH | Other: HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9 |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |