CCCTC-binding factor like [Source:HGNC Symbol;Acc:HGNC:16234]
Entrez Summary
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in
gene regulation, utilizes different zinc fingers to bind varying DNA target
sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome
inactivation. This gene is a paralog of CTCF and appears to be expressed
primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed
primarily in the nucleus of somatic cells. CTCF and the protein encoded by
this gene are normally expressed in a mutually exclusive pattern that
correlates with resetting of methylation marks during male germ cell
differentiation. Multiple alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by RefSeq, Jun
2012]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:16140944
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF