TF Info Page for CTCFL (C2H2 ZF(non-KRAB))

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: CCCTC-binding factor like [Source:HGNC Symbol;Acc:HGNC:16234]
Entrez Summary NA
Ensembl ID: ENSG00000124092
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000243914
Protein Domain: ENSP00000360239
Protein Domain: ENSP00000399061
Protein Domain: ENSP00000415579
Protein Domain: ENSP00000415329
Protein Domain: ENSP00000409344
Protein Domain: ENSP00000392034
Protein Domain: ENSP00000476577
Protein Domain: ENSP00000437999
Protein Domain: ENSP00000439998
Protein Domain: ENSP00000477165
Protein Domain: ENSP00000476783
Protein Domain: ENSP00000476458
Protein Domain: ENSP00000477488
Protein Domain: ENSP00000476718
Protein Domain: ENSP00000476398
Domain:
Protein: ENSP00000243914DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000360239DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000399061DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000415579DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000415329DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000409344DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000392034DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476577DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000437999DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000439998DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000477165DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476783DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476458DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000477488DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476718DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476398DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:16140944
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqENCODEDirect
TransfacTransfacLicense requiredDirect
MiscHOMERDirect
SMiLE-seqIsakova2017Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - Ctcf (73% AA Identity, Mus musculus)
MiscHocoMocoInferred - CTCF (73% AA Identity, Homo sapiens)
MiscHOMERInferred - CTCF (73% AA Identity, Homo sapiens)
MiscHOMERInferred - CTCF (73% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution