TF Info Page for CTCFL (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: CCCTC-binding factor like [Source:HGNC Symbol;Acc:HGNC:16234]
Entrez Summary CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Ensembl ID: ENSG00000124092
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000243914
Protein Domain: ENSP00000360239
Protein Domain: ENSP00000399061
Protein Domain: ENSP00000415579
Protein Domain: ENSP00000415329
Protein Domain: ENSP00000409344
Protein Domain: ENSP00000392034
Protein Domain: ENSP00000476577
Protein Domain: ENSP00000437999
Protein Domain: ENSP00000439998
Protein Domain: ENSP00000477165
Protein Domain: ENSP00000476783
Protein Domain: ENSP00000476458
Protein Domain: ENSP00000477488
Protein Domain: ENSP00000476718
Protein Domain: ENSP00000476398
Domain:
Protein: ENSP00000243914DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000360239DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000399061DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000415579DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000415329DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000409344DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000392034DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476577DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000437999DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000439998DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000477165DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476783DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476458DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000477488DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476718DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000476398DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:16140944
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqENCODEDirect
TransfacTransfacLicense requiredDirect
MiscHOMERDirect
SMiLE-seqIsakova2017Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-exoRhee2011Inferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CTCF (73% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - Ctcf (73% AA Identity, Mus musculus)
MiscHocoMocoInferred - CTCF (73% AA Identity, Homo sapiens)
MiscHOMERInferred - CTCF (73% AA Identity, Homo sapiens)
MiscHOMERInferred - CTCF (73% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution