TF Info Page for EGR2 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Binds HOX4A promoter (PMID:21836637)

Description

Description: early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239]
Entrez Summary The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Ensembl ID: ENSG00000122877
External Link: CisBP
Interpro IPR007087; IPR015880; IPR021849; ;
Protein Domain: ENSP00000242480
Protein Domain: ENSP00000402040
Protein Domain: ENSP00000387634
Protein Domain: ENSP00000490154
Domain:
Protein: ENSP00000242480DBD: C2H2 ZF Containing ProteinsOther: DUF3446
Protein: ENSP00000402040DBD: C2H2 ZF Containing ProteinsOther: DUF3446
Protein: ENSP00000387634DBD: C2H2 ZF Containing ProteinsOther: DUF3446
Protein: ENSP00000490154DBD: C2H2 ZF Containing ProteinsOther: DUF3446

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:12687019
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12687019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:14532282
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
RCADESchmitges2016Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
SELEXJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMDREAM_contestInferred - Egr2 (100% AA Identity, Mus musculus)
MiscHOMERInferred - Egr2 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - EGR1 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR1 (94% AA Identity, Homo sapiens)
PBMBerger06Inferred - Egr1 (94% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Egr1 (94% AA Identity, Mus musculus)
PBMZoo_01Inferred - Egr1 (94% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - EGR1 (94% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - EGR1 (94% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - EGR1 (94% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR1 (94% AA Identity, Homo sapiens)
MiscHOMERInferred - EGR1 (94% AA Identity, Homo sapiens)
PBMBadis09Inferred - Egr1 (92% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - EGR3 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR3 (90% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Egr3 (90% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - EGR3 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR3 (90% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR3 (90% AA Identity, Homo sapiens)
PBMCEPDInferred - egrh-1 (87% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - EGR4 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR4 (77% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR4 (77% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR4 (77% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution