TF Info Page for NEUROG3 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806]
Entrez Summary The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Ensembl ID: ENSG00000122859
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000242462
Domain:
Protein: ENSP00000242462DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:10757813 16511571 10757813 16511571 16511571 14576336 16511571
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:14576336
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
ISS - GO_REF:0000024
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - NEUROG2 (90% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG2 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (90% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG1 (86% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG1 (86% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (86% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (86% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Neurog1 (86% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - NEUROD1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD1 (66% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROD2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD2 (66% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (66% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (66% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NEUROD1 (66% AA Identity, Homo sapiens)
MiscHOMERInferred - Neurod1 (66% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Bhlha15 (57% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ATOH1 (54% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATOH1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (54% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Atoh1 (54% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ATOH7 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH7 (54% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ATOH1 (54% AA Identity, Homo sapiens)
SELEXJASPARInferred - Atoh1 (54% AA Identity, Mus musculus)
MiscHOMERInferred - Atoh1 (54% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - dimm (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - dimm (51% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Olig3 (50% AA Identity, Mus musculus)
MiscHOMERInferred - Olig2 (50% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution