TF Info Page for ZSCAN18 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif

Description

Description: zinc finger and SCAN domain containing 18 [Source:HGNC Symbol;Acc:HGNC:21037]
Entrez Summary NA
Ensembl ID: ENSG00000121413
External Link: CisBP
Interpro IPR003309; IPR007087; IPR008916; IPR015880;
Protein Domain: ENSP00000240727
Protein Domain: ENSP00000412253
Protein Domain: ENSP00000468934
Protein Domain: ENSP00000471570
Protein Domain: ENSP00000470123
Protein Domain: ENSP00000472129
Protein Domain: ENSP00000470329
Protein Domain: ENSP00000473019
Domain:
Protein: ENSP00000240727DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000412253DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468934DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000471570DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000470123DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000472129DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000470329DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000473019DBD: C2H2 ZF Containing ProteinsOther: SCAN

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution