TF Info Page for EGR1 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238]
Entrez Summary The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
Ensembl ID: ENSG00000120738
External Link: CisBP
Interpro IPR007087; IPR015880; IPR021839; IPR021849;
Protein Domain: ENSP00000239938
Domain:
Protein: ENSP00000239938DBD: C2H2 ZF Containing ProteinsOther: Cornifin, DUF3432, DUF3446

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:8336701 9858508 10049687
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:12560508
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
PBMBerger06Inferred - Egr1 (100% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Egr1 (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - Egr1 (100% AA Identity, Mus musculus)
PBMBadis09Inferred - Egr1 (98% AA Identity, Mus musculus)
PBMBarrera2016Inferred - EGR2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - EGR2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR2 (94% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Egr2 (94% AA Identity, Mus musculus)
SELEXJASPARInferred - EGR2 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR2 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR2 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR2 (94% AA Identity, Homo sapiens)
MiscHOMERInferred - Egr2 (94% AA Identity, Mus musculus)
PBMBarrera2016Inferred - EGR2 (92% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (92% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (92% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (92% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - EGR3 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR3 (88% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Egr3 (88% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - EGR3 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR3 (88% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR3 (88% AA Identity, Homo sapiens)
PBMCEPDInferred - egrh-1 (87% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - EGR4 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR4 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR4 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR4 (81% AA Identity, Homo sapiens)

Structure

Structure PDB 1A1F

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution