TF Info Page for MXI1 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 2 Obligate heteromer In vivo/Misc source Has a putative AT-hook Obligate heteromer (PMID: 8425219).

Description

Description: MAX interactor 1, dimerization protein [Source:HGNC Symbol;Acc:HGNC:7534]
Entrez Summary NA
Ensembl ID: ENSG00000119950
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000239007
Protein Domain: ENSP00000331152
Protein Domain: ENSP00000354606
Protein Domain: ENSP00000376842
Protein Domain: ENSP00000358625
Domain:
Protein: ENSP00000239007DBD: bHLHOther:
Protein: ENSP00000331152DBD: bHLHOther:
Protein: ENSP00000354606DBD: bHLHOther:
Protein: ENSP00000376842DBD: bHLHOther:
Protein: ENSP00000358625DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8425219 15467743
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements Obligate_Multimer

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqENCODEDirect
ChIP-seqmodENCODEDirect
ChIP-seqmodENCODEDirect
TransfacTransfacLicense requiredDirect
ChIP-seqmodENCODEInferred - mdl-1 (58% AA Identity, Caenorhabditis elegans)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution