TF Info Page for KLF9 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro

Description

Description: Kruppel like factor 9 [Source:HGNC Symbol;Acc:HGNC:1123]
Entrez Summary The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000119138
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000366330
Domain:
Protein: ENSP00000366330DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9858544 11751593
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:1356762, PMID:8051167
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMDREAM_contestInferred - Klf9 (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Klf9 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - KLF13 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF13 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF13 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF13 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ENSG00000275746 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF14 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF14 (73% AA Identity, Homo sapiens)
ChIP-seqSchmitges2016Inferred - KLF14 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Klf16 (73% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution