TF Info Page for SATB2 (CUT; Homeodomain)


Assessment Binding Mode Motif Status Notes Comments
Inferred motif 3 Low specificity DNA-binding protein In vivo/Misc source SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).


Description: SATB homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21637]
Entrez Summary This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
Ensembl ID: ENSG00000119042
External Link: CisBP
Interpro IPR001356; IPR003350; IPR009057; IPR010982;
Protein Domain: ENSP00000260926
Protein Domain: ENSP00000388581
Protein Domain: ENSP00000401112
Protein Domain: ENSP00000405420
Protein: ENSP00000260926DBD: CUT, HomeodomainOther: CUTL, ULD
Protein: ENSP00000388581DBD: CUT, HomeodomainOther: ULD
Protein: ENSP00000401112DBD: CUT, HomeodomainOther: CUTL, ULD
Protein: ENSP00000405420DBD: CUT, HomeodomainOther: CUTL, ULD

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding_
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a2, orthologous lower confidence evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - SATB1 (84% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SATB1 (84% AA Identity, Homo sapiens)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution