TF Info Page for MYB (Myb/SANT)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Contains 3 Myb DBDs

Description

Description: MYB proto-oncogene, transcription factor [Source:HGNC Symbol;Acc:HGNC:7545]
Entrez Summary NA
Ensembl ID: ENSG00000118513
External Link: CisBP
Interpro IPR001005; IPR009057; IPR012642; IPR015395; IPR017877; IPR017930;
Protein Domain: ENSP00000339992
Protein Domain: ENSP00000356788
Protein Domain: ENSP00000410825
Protein Domain: ENSP00000435938
Protein Domain: ENSP00000434723
Protein Domain: ENSP00000436605
Protein Domain: ENSP00000435055
Protein Domain: ENSP00000432851
Domain:
Protein: ENSP00000339992DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000356788DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000410825DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000435938DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000434723DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000436605DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C
Protein: ENSP00000435055DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN
Protein: ENSP00000432851DBD: Myb, Myb-Like, and SANT Domain Containing GenesOther: Cmyb_C, LMSTEN

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:12244173 15691758
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IC - GO_REF:0000036
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBadis09Inferred - Myb (78% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - Myb (78% AA Identity, Mus musculus)
MiscHOMERInferred - Myb (78% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - MYB_AVIMB (75% AA Identity, Avian myeloblastosis virus)
TransfacTransfacLicense requiredInferred - MYB_AVIMB (75% AA Identity, Avian myeloblastosis virus)
PBMBadis09Inferred - Mybl1 (72% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - MYBL2 (72% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MYBL2 (72% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Mybl2 (72% AA Identity, Mus musculus)
MiscHocoMocoInferred - MYBL2 (72% AA Identity, Homo sapiens)
MiscHOMERInferred - MYBL2 (72% AA Identity, Homo sapiens)

Structure

Structure PDB 1MSE

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution