TF Info Page for PLAGL1 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: PLAG1 like zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:9046]
Entrez Summary This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Ensembl ID: ENSG00000118495
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000346810
Protein Domain: ENSP00000356543
Protein Domain: ENSP00000356544
Protein Domain: ENSP00000376124
Protein Domain: ENSP00000400060
Protein Domain: ENSP00000395960
Protein Domain: ENSP00000392418
Protein Domain: ENSP00000400929
Protein Domain: ENSP00000487447
Protein Domain: ENSP00000486711
Protein Domain: ENSP00000486763
Protein Domain: ENSP00000486355
Domain:
Protein: ENSP00000346810DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000356543DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000356544DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000376124DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000400060DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000395960DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000392418DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000400929DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000487447DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000486711DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000486763DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000486355DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9671765 9722527
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:9671765
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
MiscHocoMocoDirect
PBMBadis09Inferred - Plagl1 (87% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution