TF Info Page for KLF7 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect

Description

Description: Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350]
Entrez Summary The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Ensembl ID: ENSG00000118263
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000309570
Protein Domain: ENSP00000387510
Protein Domain: ENSP00000398572
Protein Domain: ENSP00000393268
Protein Domain: ENSP00000403284
Protein Domain: ENSP00000413590
Domain:
Protein: ENSP00000309570DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000387510DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000398572DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000393268DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000403284DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000413590DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9774444
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
ChIP-seqSchmitges2016Direct
PBMBadis09Inferred - Klf7 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - KLF6 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF6 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF6 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - KLF6 (94% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - luna (93% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - KLF12 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF12 (83% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF12 (83% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Klf12 (83% AA Identity, Mus musculus)
ChIP-seqSchmitges2016Inferred - KLF12 (83% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF12 (83% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF5 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF5 (82% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - KLF5 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF5 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF5 (82% AA Identity, Homo sapiens)
MiscHOMERInferred - KLF5 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF3 (80% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF3 (80% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF3 (80% AA Identity, Homo sapiens)
MiscHocoMocoInferred - KLF3 (80% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - KLF1 (79% AA Identity, Homo sapiens)
ChIP-seqSchmitges2016Inferred - KLF1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF1 (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF1 (79% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Klf1 (79% AA Identity, Mus musculus)
MiscHocoMocoInferred - KLF1 (79% AA Identity, Homo sapiens)
MiscHOMERInferred - Klf1 (79% AA Identity, Mus musculus)
PBMBarrera2016Inferred - KLF1 (78% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - KLF1 (78% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - KLF1 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF2 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF2 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF4 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF2 (78% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - KLF4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - KLF4 (78% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - Klf4 (78% AA Identity, Mus musculus)
ChIP-seqJASPARInferred - Klf4 (78% AA Identity, Mus musculus)
MiscHocoMocoInferred - KLF4 (78% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Klf8 (73% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - KLF8 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - KLF8 (73% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution