TF Info Page for KMT2A (CxxC; AT hook)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 3 AT-hook domain, a CXXC domain, and a possible C2H2 domain.


Description: lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]
Entrez Summary This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Ensembl ID: ENSG00000118058
External Link: CisBP
Interpro IPR001214; IPR001487; IPR001965; IPR002857; IPR003616; IPR003888; IPR003889; IPR011011; IPR016569; IPR019787;
Protein Domain: ENSP00000374157
Protein Domain: ENSP00000376612
Protein Domain: ENSP00000436786
Protein Domain: ENSP00000436564
Protein Domain: ENSP00000432391
Protein Domain: ENSP00000434618
Protein Domain: ENSP00000436700
Protein Domain: ENSP00000432652
Protein: ENSP00000374157DBD: CxxCOther: Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC
Protein: ENSP00000376612DBD: CxxCOther: PHD, PHD_2, PHD_4, zf-PHD-like
Protein: ENSP00000436786DBD: CxxCOther: Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC
Protein: ENSP00000436564DBD: CxxCOther:
Protein: ENSP00000432391DBD: CxxCOther:
Protein: ENSP00000434618DBD: CxxCOther:
Protein: ENSP00000436700DBD: CxxCOther:
Protein: ENSP00000432652DBD: CxxCOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
NAS - PMID:10821850
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution