get eID ENSG00000117707 else done selects

TF Info Page for PROX1 (Prospero)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459]
Entrez Summary TBA
Ensembl ID: ENSG00000117707
External Link: T137762_1.02
Interpro IPR009057; IPR023082;
Protein Domain:
Protein: ENSP00000261454DBD: Homeo-prospero domainOther:
Protein: ENSP00000355925DBD: Homeo-prospero domainOther:
Protein: ENSP00000400694DBD: Homeo-prospero domainOther:
Protein: ENSP00000420283DBD: Homeo-prospero domainOther:
Protein: ENSP00000419517DBD: Homeo-prospero domainOther:
Protein: ENSP00000475357DBD: Homeo-prospero domainOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
IC - PMID:19210544
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
ISS - GO_REF:0000024
GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:15205472, PMID:16488887
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution