TF Info Page for IRF6 (IRF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121]
Entrez Summary This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Ensembl ID: ENSG00000117595
External Link: CisBP
Interpro IPR001346; IPR008984; IPR019471; IPR019817;
Protein Domain: ENSP00000355988
Protein Domain: ENSP00000440532
Protein Domain: ENSP00000403855
Domain:
Protein: ENSP00000355988DBD: Interferon regulatory factor (IRF)Other: IRF-3
Protein: ENSP00000440532DBD: Interferon regulatory factor (IRF)Other: IRF-3
Protein: ENSP00000403855DBD: Interferon regulatory factor (IRF)Other: IRF-3

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
ISS - GO_REF:0000024
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMBadis09Inferred - Irf6 (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - IRF6 (93% AA Identity, Meleagris gallopavo)
PBMZoo_01Inferred - IRF6 (92% AA Identity, Gallus gallus)
PBMZoo_01Inferred - irf6.2 (91% AA Identity, Xenopus tropicalis)
PBMZoo_01Inferred - AAH82862 (79% AA Identity, Xenopus laevis)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution