TF Info Page for KDM5B (ARID/BRIGHT)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Binds GC-rich sequences such as CCGCCC (PMID: 18270511).


Description: lysine demethylase 5B [Source:HGNC Symbol;Acc:HGNC:18039]
Entrez Summary This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Ensembl ID: ENSG00000117139
External Link: CisBP
Interpro IPR001606; IPR001965; IPR003347; IPR003349; IPR004198; IPR011011; IPR013637; IPR019786; IPR019787; ;
Protein Domain: ENSP00000356233
Protein Domain: ENSP00000356234
Protein Domain: ENSP00000235790
Protein: ENSP00000356233DBD: ARID/BRIGHTOther: JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2
Protein: ENSP00000356234DBD: ARID/BRIGHTOther: JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2
Protein: ENSP00000235790DBD: ARID/BRIGHTOther: JmjC, PHD, PHD_2, PLU-1, zf-C5HC2, zf-PHD-like

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_Transcription Factor Binding
tf co-factor binding_TF PPI
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:10336460
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution