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This gene is a member of the myocyte-specific enhancer factor 2
(MEF2) family of transcription factors. Members of this family are involved
in control of muscle and neuronal cell differentiation and development, and
are regulated by class II histone deacetylases. Fusions of the encoded
protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a
translocation have been found in an acute lymphoblastic leukemia cell line,
suggesting a role in leukemogenesis. The encoded protein may also be involved
in Parkinson disease and myotonic dystrophy. Alternative splicing results in
multiple transcript variants. [provided by RefSeq, Oct 2012]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:20590529 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:8575763
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF