TF Info Page for ARID3A (ARID/BRIGHT)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro

Description

Description: AT-rich interaction domain 3A [Source:HGNC Symbol;Acc:HGNC:3031]
Entrez Summary This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000116017
External Link: CisBP
Interpro IPR001606; IPR023334;
Protein Domain: ENSP00000263620
Protein Domain: ENSP00000464969
Domain:
Protein: ENSP00000263620DBD: ARID/BRIGHTOther:
Protein: ENSP00000464969DBD: ARID/BRIGHTOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:15456761
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
other
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHocoMocoDirect
PBMZoo_01Inferred - ARID3A (100% AA Identity, Microcebus murinus)
PBMBadis09Inferred - Arid3a (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - Arid3a (100% AA Identity, Mus musculus)
SELEXJASPARInferred - Arid3a (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - ARID3A (98% AA Identity, Procavia capensis)
PBMZoo_01Inferred - Arid3b (89% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - retn (83% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - retn (83% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - retn (83% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - cfi-1 (75% AA Identity, Caenorhabditis elegans)
PBMZoo_01Inferred - ACYPI009013 (64% AA Identity, Acyrthosiphon pisum)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution