TF Info Page for ATF2 (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: activating transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:784]
Entrez Summary NA
Ensembl ID: ENSG00000115966
External Link: CisBP
Interpro IPR004827; IPR007087; IPR016378; ;
Protein Domain: ENSP00000264110
Protein Domain: ENSP00000340576
Protein Domain: ENSP00000376327
Protein Domain: ENSP00000386282
Protein Domain: ENSP00000386526
Protein Domain: ENSP00000407911
Domain:
Protein: ENSP00000264110DBD: bZIPOther:
Protein: ENSP00000340576DBD: bZIPOther:
Protein: ENSP00000376327DBD: bZIPOther:
Protein: ENSP00000386282DBD: bZIPOther:
Protein: ENSP00000386526DBD: bZIPOther:
Protein: ENSP00000407911DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_Transactivation_
PMIDS:1658708 2529117 9139739 10909971
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IC - GO_REF:0000036
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:8798441
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IC - PMID:19861239
GO:0051090
regulation of sequence-specific DNA binding transcription factor activity
TAS - Reactome:R-HSA-450341
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IMP - PMID:10821277
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
PBMZoo_01Inferred - Atf2 (100% AA Identity, Mus musculus)
MiscHOMERInferred - Atf2 (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - Atf7 (82% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - CREB5 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB5 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB5 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB5 (81% AA Identity, Homo sapiens)

Structure

Structure PDB 1T2K

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution