get eID ENSG00000115507 else done selects

TF Info Page for OTX1 (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521]
Entrez Summary TBA
Ensembl ID: ENSG00000115507
External Link: T093272_1.02
Interpro IPR001356; IPR003025; IPR003026; IPR009057; IPR013851; IPR017970;
Protein Domain:
Protein: ENSP00000282549DBD: HomeodomainOther: TF_Otx
Protein: ENSP00000355631DBD: HomeodomainOther: TF_Otx

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:18849347
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBerger08Inferred - Otx1 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - OTX2 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX2 (98% AA Identity, Homo sapiens)
PBMBerger08Inferred - Otx2 (98% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - OTX2 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - OTX2 (98% AA Identity, Homo sapiens)
MiscHocoMocoInferred - OTX2 (98% AA Identity, Homo sapiens)
MiscHOMERInferred - Otx2 (98% AA Identity, Mus musculus)
B1HJASPARInferred - oc (96% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - oc (96% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - oc (96% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - CRX (91% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - CRX (89% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CRX (89% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CRX (89% AA Identity, Homo sapiens)
PBMBerger08Inferred - Crx (89% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - CRX (89% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - CRX (89% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Crx (89% AA Identity, Mus musculus)
MiscHocoMocoInferred - CRX (89% AA Identity, Homo sapiens)
MiscHOMERInferred - Crx (89% AA Identity, Mus musculus)
PBMBarrera2016Inferred - CRX (87% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - CRX (87% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - CRX (87% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - CRX (83% AA Identity, Homo sapiens)
B1HJASPARInferred - CG11294 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - DRGX (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DRGX (70% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Drgx (70% AA Identity, Rattus norvegicus)
PBMBerger08Inferred - Otp (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - PHOX2A (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2A (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2a (68% AA Identity, Mus musculus)
PBMBarrera2016Inferred - PHOX2B (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2b (68% AA Identity, Mus musculus)
MiscHOMERInferred - Phox2a (68% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - CG2808 (66% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - PHOX2B (66% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution